Stary-Weinzinger, A. : rechercher sur Z-Library

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1

Grayanotoxin Poisoning: ‘Mad Honey Disease’ and Beyond

Suze A. Jansen, Iris Kleerekooper, Zonne L. M. Hofman, Isabelle F. P. M. Kappen, Anna Stary-Weinzinger, Marcel A. G. van der Heyden

Journal:

Cardiovascular Toxicology

Année:

2012

Langue:

english

Fichier:

PDF, 293 KB

english, 2012

2

Mechanism of hERG Channel Block by the Psychoactive Indole Alkaloid Ibogaine

Thurner, P., Stary-Weinzinger, A., Gafar, H., Gawali, V. S., Kudlacek, O., Zezula, J., Hilber, K., Boehm, S., Sandtner, W., Koenig, X.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Année:

2014

Langue:

english

Fichier:

PDF, 1.25 MB

english, 2014

3

Timothy mutation affects tightly sealing point of CaV1.2 activation gate

Katrin Depil, Stanislav Beyl, Anna Stary-Weinzinger, Annette Hohaus, Eugen Timin, Steffen Hering

Journal:

BMC Pharmacology

Année:

2011

Langue:

english

Fichier:

PDF, 71 KB

english, 2011

4

Physicochemical properties of pore residues predict activation gating of CaV1.2: A correlation mutation analysis

Stanislav Beyl, Katrin Depil, Annette Hohaus, Anna Stary-Weinzinger, Eugen Timin, Waheed Shabbir, Michaela Kudrnac, Steffen Hering

Journal:

Pflügers Archiv European Journal of Physiology

Année:

2011

Langue:

english

Fichier:

PDF, 370 KB

english, 2011

5

Cysteines in the loop between IS5 and the pore helix of CaV3.1 are essential for channel gating

Maria Karmazinova, Stanislav Beyl, Anna Stary-Weinzinger, Chonticha Suwattanasophon, Norbert Klugbauer, Steffen Hering, Lubica Lacinova

Journal:

Pflügers Archiv European Journal of Physiology

Année:

2010

Langue:

english

Fichier:

PDF, 629 KB

english, 2010

6

Neutralizing the Charges in a Voltage Sensor Repairs Gating Perturbations in the Pore of CaV1.2

Beyl, Stanislav, Depil, Katrin, Hohaus, Annette, Stary-Weinzinger, Anna, Timin, Eugen, Hering, Steffen

Journal:

Biophysical Journal

Année:

2012

Langue:

english

Fichier:

PDF, 62 KB

english, 2012

7

ICA105574 Binds to a Similar Region of the Pore Domain to Induce Opposite Effects on the Gating of EAG and ERG Channels

Garg, Vivek, Stary-Weinzinger, Anna, Sanguinetti, Michael C.

Journal:

Biophysical Journal

Année:

2012

Langue:

english

Fichier:

PDF, 65 KB

english, 2012

8

Distinct interactions of Na+ and Ca2+ ions with the selectivity filter of the bacterial sodium channel NaVAb

Ke, Song, Zangerl, Eva-Maria, Stary-Weinzinger, Anna

Journal:

Biochemical and Biophysical Research Communications

Année:

2013

Langue:

english

Fichier:

PDF, 769 KB

english, 2013

9

Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue

Varkevisser, R, Houtman, M J C, Linder, T, de Git, K C G, Beekman, H D M, Tidwell, R R, IJzerman, A P, Stary-Weinzinger, A, Vos, M A, van der Heyden, M A G

Journal:

British Journal of Pharmacology

Année:

2013

Langue:

english

Fichier:

PDF, 1.64 MB

english, 2013

10

Computational Insights into Atomistic Details of Na+ Versus Ca2+ Discrimination in Sodium Channel NavAb

Ke, Song, Stary-Weinzinger, Anna

Journal:

Biophysical Journal

Année:

2013

Langue:

english

Fichier:

PDF, 36 KB

english, 2013

11

Inactivation Properties, not Binding Site Differences, Govern Reciprocal Functional Response to ICA105574 in EAG and ERG Potassium Channels

Garg, Vivek, Stary-Weinzinger, Anna, Sanguinetti, Michael C.

Journal:

Biophysical Journal

Année:

2013

Langue:

english

Fichier:

PDF, 41 KB

english, 2013

12

Pore Gating of K+ Channels Studied by Essential Dynamics Simulations using the Simplified Bacterial K+ Channel KcsA

Linder, Tobias, Stary-Weinzinger, Anna

Journal:

Biophysical Journal

Année:

2012

Langue:

english

Fichier:

PDF, 39 KB

english, 2012

13

Activation Gating of KcsA: New Insights into Cooperativity and Energy Landscape from Essential Dynamics Simulations

Linder, Tobias, Stary-Weinzinger, Anna

Journal:

Biophysical Journal

Année:

2013

Langue:

english

Fichier:

PDF, 56 KB

english, 2013

14

Drug Trapping in hERG Channels does not Require Closure of the Activation Gate

Saxena, Priyanka, Erker, Thomas, Bauer, Florian, Stary-Weinzinger, Anna, Linder, Tobias, Hering, Steffen, Timin, Eugen

Journal:

Biophysical Journal

Année:

2013

Langue:

english

Fichier:

PDF, 41 KB

english, 2013

15

Insights into Molecular Basis of hERG Inhibition by Studying a Library of Dofetilide Derivatives

Saxena, Priyanka, Linder, Tobias, Stary-Weinzinger, Anna, IJzerman, Adriaan P., Timin, Eugen, Franz Ecker, Gerhard, Hering, Steffen

Journal:

Biophysical Journal

Année:

2014

Langue:

english

Fichier:

PDF, 45 KB

english, 2014

16

A Novel Gating Mechanism of the NaVMs Selectivity Filter Suggested by Molecular Dynamics Simulations

Ke, Song, Stary-Weinzinger, Anna

Journal:

Biophysical Journal

Année:

2014

Langue:

english

Fichier:

PDF, 46 KB

english, 2014

17

Physicochemical Properties of Pore Residues Predict Activation Gating of Cav1.2: A Correlation Mutation Analysis

Depil, Katrin, Beyl, Stanislav, Hohaus, Annette, Stary-Weinzinger, Anna, Timin, Eugen, Shabbir, Waheed, Kudrnac, Michaela, Hering, Steffen

Journal:

Biophysical Journal

Année:

2011

Langue:

english

Fichier:

PDF, 40 KB

english, 2011

18

Surprises from an Unusual CLC Homolog

Phillips, Sabrina, Brammer, Ashley E., Rodriguez, Luis, Lim, Hyun-Ho, Stary-Weinzinger, Anna, Matulef, Kimberly

Journal:

Biophysical Journal

Année:

2012

Langue:

english

Fichier:

PDF, 244 KB

english, 2012

19

Computer Simulations of Structure–Activity Relationships for hERG Channel Blockers

Boukharta, Lars, Keränen, Henrik, Stary-Weinzinger, Anna, Wallin, Göran, de Groot, Bert L., Åqvist, Johan

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 3.29 MB

english, 2011

20

Insights in KIR2.1 channel structure and function by an evolutionary approach; cloning and functional characterization of the first reptilian inward rectifier channel KIR2.1, derived from the California kingsnake (Lampropeltis getula californiae)

Houtman, Marien J.C., Korte, Sanne M., Ji, Yuan, Kok, Bart, Vos, Marc A., Stary-Weinzinger, Anna, van der Heyden, Marcel A.G.

Journal:

Biochemical and Biophysical Research Communications

Année:

2014

Langue:

english

Fichier:

PDF, 1.29 MB

english, 2014

21

Structural Insights into Trapping and Dissociation of Small Molecules in K + Channels

Linder, Tobias, Saxena, Priyanka, Timin, Eugen, Hering, Steffen, Stary-Weinzinger, Anna

Journal:

Journal of Chemical Information and Modeling

Année:

2014

Langue:

english

Fichier:

PDF, 4.06 MB

english, 2014

22

Efficient and specific cardiac IK1 inhibition by a new pentamidine analogue

Takanari, H., Nalos, L., Stary-Weinzinger, A., de Git, K. C. G., Varkevisser, R., Linder, T., Houtman, M. J. C., Peschar, M., de Boer, T. P., Tidwell, R. R., Rook, M. B., Vos, M. A., van der Heyden, M

Journal:

Cardiovascular Research

Année:

2013

Langue:

english

Fichier:

PDF, 2.72 MB

english, 2013

23

Timothy Mutation Disrupts the Link between Activation and Inactivation in CaV1.2 Protein

Depil, K., Beyl, S., Stary-Weinzinger, A., Hohaus, A., Timin, E., Hering, S.

Journal:

Journal of Biological Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 2.56 MB

english, 2011

24

Exploring the Structure of the Voltage-gated Na + Channel by an Engineered Drug Access Pathway to the Receptor Site for Local Anesthetics

Lukacs, Peter, Gawali, Vaibhavkumar S., Cervenka, Rene, Ke, Song, Koenig, Xaver, Rubi, Lena, Zarrabi, Touran, Hilber, Karlheinz, Stary-Weinzinger, Anna, Todt, Hannes

Journal:

Journal of Biological Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 2.09 MB

english, 2014

25

ICA-105574 Interacts with a Common Binding Site to Elicit Opposite Effects on Inactivation Gating of EAG and ERG Potassium Channels

Garg, V., Stary-Weinzinger, A., Sanguinetti, M. C.

Journal:

Molecular Pharmacology

Année:

2013

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2013

26

Molecular Determinants for Activation of Human Ether-a-go-go-related Gene 1 Potassium Channels by 3-Nitro-N-(4-phenoxyphenyl) Benzamide

Garg, V., Stary-Weinzinger, A., Sachse, F., Sanguinetti, M. C.

Journal:

Molecular Pharmacology

Année:

2011

Langue:

english

Fichier:

PDF, 2.46 MB

english, 2011

27

Molecular Dynamics Simulations of KirBac1.1 Mutants Reveal Global Gating Changes of Kir Channels

Linder, Tobias, Wang, Shizhen, Zangerl-Plessl, Eva-Maria, Nichols, Colin G., Stary-Weinzinger, Anna

Journal:

Journal of Chemical Information and Modeling

Année:

2015

Langue:

english

Fichier:

PDF, 529 KB

english, 2015

28

Probing the Energy Landscape of Activation Gating of the Bacterial Potassium Channel KcsA

Linder, Tobias, de Groot, Bert L., Stary-Weinzinger, Anna, Tajkhorshid, Emad

Journal:

PLoS Computational Biology

Année:

2013

Langue:

english

Fichier:

PDF, 1.10 MB

english, 2013

29

Different Inward and Outward Conduction Mechanisms in NaVMs Suggested by Molecular Dynamics Simulations

Ke, Song, Timin, E. N., Stary-Weinzinger, Anna, Tajkhorshid, Emad

Journal:

PLoS Computational Biology

Année:

2014

Langue:

english

Fichier:

PDF, 3.95 MB

english, 2014

30

Drug trapping in hERG K + channels: (not) a matter of drug size?

Linder, Tobias, Bernsteiner, Harald, Saxena, Priyanka, Bauer, Florian, Erker, Thomas, Timin, Eugen, Hering, Steffen, Stary-Weinzinger, Anna

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 2.25 MB

english, 2016

31

Studying the Gating Mechanism of Mammalian Kir Channels using in Silico Mutations

Zangerl, Eva-Maria, Stary-Weinzinger, Anna

Journal:

Biophysical Journal

Année:

2015

Langue:

english

Fichier:

PDF, 42 KB

english, 2015

32

Towards a Structural Understanding of Cantú Disease Associated Gating Perturbations in the KATP Potassium Channel

Plessl, Eva-Maria, Stary-Weinzinger, Anna

Journal:

Biophysical Journal

Année:

2016

Langue:

english

Fichier:

PDF, 58 KB

english, 2016

33

Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids

Lee, Sun-Joo, Ren, Feifei, Zangerl-Plessl, Eva-Maria, Heyman, Sarah, Stary-Weinzinger, Anna, Yuan, Peng, Nichols, Colin G.

Journal:

The Journal of General Physiology

Année:

2016

Langue:

english

Fichier:

PDF, 2.39 MB

english, 2016

34

New potential binding determinant for hERG channel inhibitors

Saxena, P., Zangerl-Plessl, E.-M., Linder, T., Windisch, A., Hohaus, A., Timin, E., Hering, S., Stary-Weinzinger, A.

Journal:

Scientific Reports

Année:

2016

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2016

35

Investigating the Gating Mechanism of G Protein-Activated Inward Rectifying Potassium Channels

Bernsteiner, Harald, Stary-Weinzinger, Anna

Journal:

Biophysical Journal

Année:

2017

Langue:

english

Fichier:

PDF, 45 KB

english, 2017

36

Dynamics of the EAG1 K+ channel selectivity filter assessed by molecular dynamics simulations

Bernsteiner, Harald, Bründl, Michael, Stary-Weinzinger, Anna

Journal:

Biochemical and Biophysical Research Communications

Année:

2017

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2017

37

Computational Investigations of KATP Channel Pore Blockers

Chen, Xingyu, Zangerl-Plessl, Eva-Maria, Stary-Weinzinger, Anna

Journal:

Biophysical Journal

Année:

2017

Langue:

english

Fichier:

PDF, 48 KB

english, 2017

38

Conserved functional consequences of disease-associated mutations in the slide-helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel

Cooper, Paige E, McClenaghan, Conor, Chen, Xingyu, Stary-Weinzinger, Anna, Nichols, Colin G.

Journal:

Journal of Biological Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.26 MB

english, 2017

39

Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na+ channels: mechanistic insights from recent crystal structures

Cervenka, Rene, Lukacs, Peter, Gawali, Vaibhavkumar S., Ke, Song, Koenig, Xaver, Rubi, Lena, Zarrabi, Touran, Hilber, Karlheinz, Sandtner, Walter, Stary-Weinzinger, Anna, Todt, Hannes

Journal:

Scientific Reports

Année:

2018

Langue:

english

Fichier:

PDF, 2.11 MB

english, 2018

40

Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole

Gualdani, Roberta, Cavalluzzi, Maria Maddalena, Tadini-Buoninsegni, Francesco, Convertino, Marino, Gailly, Philippe, Stary-Weinzinger, Anna, Lentini, Giovanni

Journal:

Cellular Physiology and Biochemistry

Année:

2018

Langue:

english

Fichier:

PDF, 1.98 MB

english, 2018

41

Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa , are I Kr blockers with proarrhythmic effects in vitro and in vivo

Baburin, Igor, Varkevisser, Rosanne, Schramm, Anja, Saxena, Priyanka, Beyl, Stanislav, Szkokan, Phillip, Linder, Tobias, Stary-Weinzinger, Anna, van der Heyden, Marcel A.G., Houtman, Marien, Takanari,

Journal:

Pharmacological Research

Année:

2018

Langue:

english

Fichier:

PDF, 4.42 MB

english, 2018

42

PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression

Ji, Yuan, Veldhuis, Marlieke G., Zandvoort, Jantien, Romunde, Fee L., Houtman, Marien J. C., Duran, Karen, van Haaften, Gijs, Zangerl-Plessl, Eva-Maria, Takanari, Hiroki, Stary-Weinzinger, Anna, van d

Journal:

Journal of Biomedical Science

Année:

2017

Langue:

english

Fichier:

PDF, 1.67 MB

english, 2017

43

Selectivity Profiling of the Human Monoamine Transporters: Investigation of the Serotonin Transporter Mechanism

Hellsberg, Eva, Forrest, Lucy R., Stary-Weinzinger, Anna, Ecker, Gerhard F.

Journal:

Biophysical Journal

Année:

2018

Langue:

english

Fichier:

PDF, 45 KB

english, 2018

44

A structural model of the human serotonin transporter in an outward-occluded state

Hellsberg, Eva, Ecker, Gerhard F., Stary-Weinzinger, Anna, Forrest, Lucy R., Soares, Claudio M.

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 3.00 MB

english, 2019

45

Conduction through a narrow inward-rectifier K + channel pore

Bernsteiner, Harald, Zangerl-Plessl, Eva-Maria, Chen, Xingyu, Stary-Weinzinger, Anna

Journal:

The Journal of General Physiology

Année:

2019

Langue:

english

Fichier:

PDF, 2.65 MB

english, 2019

46

Disease Associated Mutations in KIR Proteins Linked to Aberrant Inward Rectifier Channel Trafficking

Zangerl-Plessl, Eva-Maria, Qile, Muge, Bloothooft, Meye, Stary-Weinzinger, Anna, van der Heyden, Marcel A. G.

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 2.00 MB

english, 2019

47

Towards a structural view of hERG activation by the small molecule activator ICA-105574

Zangerl-Plessl, Eva-Maria, Berger, Martin, Drescher, Martina, Chen, Yong, Wu, Wei, Maulide, Nuno, Sanguinetti, Michael, Stary-Weinzinger, Anna

Journal:

Journal of Chemical Information and Modeling

Année:

2019

Langue:

english

Fichier:

PDF, 3.92 MB

english, 2019

48

Towards a structural view of hERG activation by the small molecule activator ICA-105574

Zangerl-Plessl, Eva-Maria, Berger, Martin, Drescher, Martina, Chen, Yong, Wu, Wei, Maulide, Nuno, Sanguinetti, Michael, Stary-Weinzinger, Anna

Journal:

Journal of Chemical Information and Modeling

Année:

2019

Fichier:

PDF, 3.92 MB

2019

49

LUF7244 plus Dofetilide Rescues Aberrant K v 11.1 Trafficking and Produces Functional I Kv11.1

Qile, Muge, Ji, Yuan, Golden, Tyona D., Houtman, Marien J.C., Romunde, Fee, Fransen, Doreth, van Ham, Willem B., IJzerman, Ad P., January, Craig T., Heitman, Laura H., Stary-Weinzinger, Anna, Delisle,

Journal:

Molecular Pharmacology

Année:

2020

Fichier:

PDF, 13.30 MB

2020

50

Computational Insights Into Voltage Dependence of Polyamine Block in a Strong Inwardly Rectifying K+ Channel

Chen, Xingyu, BrÃ¼ndl, Michael, Friesacher, Theres, Stary-Weinzinger, Anna

Journal:

Frontiers in Pharmacology

Année:

2020

Fichier:

PDF, 2.63 MB

2020